多媒體教學系統

正規課程(38)

研討會&非正規課程(3)

Special Topics on Epigenetics (II)

授課年級: 各學院研究所學生。
修課人數: 限 21 名。
時間: 星期五，5 - 6節 ( 13：10 - 15：00 )。
地點: 醫學院0724教室。
教科書: 使用自編的講義。
課程目的: 使學生了解並熟悉各種表觀遺傳學之概念及方法，培養學生應用此一新穎科學於研究之能力。
協調老師: 蔡少正 (Phone: 5426)。
參考書目:
1. Scientific papers。
2. Journal articles。
課程要求：課前下載上課之power point檔預習，上課中除課程講授外，著重討論以及課中及課後之寫作練習。
評量方式：平時成績(包括上課表現，每週作業)佔50%，期末考試佔50%。

Date	Lecture	Speaker	Topic
2013-02-22	1	S. Tsai	Introduction
2013-03-01	2	祐華	(1) Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells
2013-03-08	3	依涵	(2) TET2 promotes histone O-GlcNAcylation during gene transcription
2013-03-15	4	舒婷	(3) TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
2013-03-22	5		Review 1
2013-03-29	6	佳玲	(5) Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
2013-04-05	7		Spring Break
2013-04-12	8	Peggy	(4) MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
2013-04-19	9	奕漢	(6) EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
2013-04-26	10		Review 2
2013-05-03	11	薇軒	(7) Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
2013-05-10	12	脩琦	(8) Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
2013-05-17	13	郡緯	(9) In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
2013-05-24	14	致豪	(10) β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
2013-05-31	15		Review 3
2013-06-07	16	毓娟	(11) DNA synthesis is required for reprogramming mediated by stem cell fusion
2013-06-14	17	張寧	(12) The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
2013-06-21	18		Final Exam