多媒體教學系統

正規課程(38)

研討會&非正規課程(3)

人類致病基因定位的策略與方法

授課年級: 醫學院臨醫所、分醫所、基醫所及其他院所研究生 (上限25人)
授課老師: 孫孝芳（成大分醫所, 統一健康大樓 4303,Phone:3648）
郭柏秀（成大臨醫所, 醫院12C, Phone: 4414）
時間: Wed, 9-10節 (5：30PM - 7：00 PM)
地點: 統一健康大樓1004研討室
課程目的: Introduce a series of fundamental genetic concepts, apply genetic approaches to understand familial aggregation and gene mapping for both qualitative and quantitative traits
評量方式: Class Participation 30%, Mid-term 40%, Presentation 30%
參考書: Approaches to Gene Mapping in Complex Human Disease, by Haines and Pericak-Vance
Fundamentals of Genetic Epidemiology, by Khour, Beaty, and Cohen
Current protocols in human genetics
Principles of Population Genetics, by Hartl and Clark Analysis of Human Genetic Linkage, by Jurg Ott Statistical Methods in Genetic Epidemiology, by Duncan Thomas (Oxford University Press)

Date	Lecture	Speaker	Topic
2009-02-18	1	孫孝芳	Course and basic gene mapping introduction/Mendelian & Non-Mendelian Inheritance; collection of clinical data for genetic
2009-02-25	2	林秀娟	studies
2009-03-04	3	孫孝芳	Basic concepts of linkage analysis
2009-03-11	4	孫孝芳	Positional cloning
2009-03-18	5	孫孝芳	Alternative study designs (Sib-pair analysis and homozygosity mapping)/Familial Aggregation: Correlation, Recurrence Risk Ratio, and Genotype Relative
2009-03-25	6	郭柏秀	Risk
2009-04-01	7		Spring break (no class)
2009-04-08	8	郭柏秀	Determining the genetic component of a disease & quantitative genetics
2009-04-15	9	孫孝芳	Midterm examine
2009-04-22	10	郭柏秀	Population Genetics: Hardy-Weinberg Equilibrium & Linkage Disequilibrium
2009-04-29	11	郭柏秀	Association Studies: Family-based association
2009-05-06	12	郭柏秀	Population-based association & whole-genome association
2009-05-13	13	郭柏秀	Hands-on: Linkage Analysis & Association Study
2009-05-20	14	孫孝芳	Sequence analysis
2009-05-27	15	孫孝芳/郭柏秀	Paper discussion I
2009-06-03	16	孫孝芳/郭柏秀	Paper discussion II
2009-06-10	17	孫孝芳/郭柏秀	Paper discussion III
2009-06-17	18	孫孝芳/郭柏秀	Paper discussion III